Spiro : 1: American shortened form of Greek Spiros or of any of various derivatives of this personal name.2: Jewish (Ashkenazic): habitational name from Shpire the Yiddish name of the German city of Speyer (see Speyer). Compare Shapiro.

Source : DAFN2 : Dictionary of American Family Names 2nd edition, ©2022 by Patrick Hanks and Oxford University Press

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